Chapter Listing
Introduction to epilepsy
Classification of seizures
Abnormal EEG activity
Non-epileptic EEG activity
Sleep and epilepsy
Sleep Fragmentation and Decreased REM
History of seizures in sleep
Janz Study – Epilepsy
When do seizures occur?
Why do seizures occur in sleep?
Sleep and epilepsy are interrelated
Cortical hyperexcitability
Sleep activates epileptic cortex
Anatomical location
REM sleep
Bidirectional Relationship
Sleep EEF Findings
Epilepsy affects sleep organization
GTCS Reduce REM sleep
Sleep is Affected on seizure free nights
TLE Reduces REM sleep
Spikes and Sharp waves in K-complexes
Features of nocturnal seizures
Manifestations of seizures
Diagnosis of seizures in sleep
SHE vs parasomnias
Sleep-related epilepsy syndromes
Temporal lobe epilepsy
Sleep Activates TLE
Hippocampal-Cortical Coupling
Temporal Lobe Seizures
Circadian Pattern of Seizures
Benign Rolandic epilepsy
Lennox-Gastaut syndrome
LGS and Cannabinoids
SHE
Sensorimotor seizures
Autosomal dominant epilepsy
Frontal lobe seizures
Insula-opercular seizures
Landau-Kleffner Syndrome
Focal Cortical Dysplasia
Continuous spikewave epilepsy
Pseudoseizures
Tonic seizures
Juvenile myoclonic epilepsy
SWA and Focal Epilepsy
Dravet Syndrome
Cannabinoids and Dravet Syndrome
Tuberous sclerosis
Treatment of Electrical Status Epilepticus
Prognosis of seizures in sleep
Anti-epileptic medications
AED’s and sleep organization
Vagus nerve stimulator
Ketogenic Dietary Therapy
Summary: Seizures in Sleep
Sleepiness in epilepsy
Evaluating sleepiness
Insomnia in epilepsy
Sleep, breathing and epilepsy
Sleep apnea and epilepsy
Sleep Paralysis in Epilespy
CPAP and epilepsy
Mechanisms of seizure facilitation
SDB and epilepsy
Reduction in Seizures with CPAP
Paroxysmal Non-Epileptic Events
Sudden Unexplained Death in Epilepsy
SHE and KCNT1 Mutations
Conclusions
